1,1'-Biphenyl, mixt. with 1,1'-oxybis(benzene) → 2-(4-Methoxyphenyl)-5-methyloxazole

HRID 359836Notes

Reaction equation

HRID 359836 reaction equation
C[C:2]1[N:3]=[C:4]([C:8]2[CH:13]=[CH:12][C:11]([OH:14])=[CH:10][CH:9]=2)[O:5][C:6]=1[CH3:7].[CH:15]1C=CC(C2C=CC=CC=2)=CC=1.C1C=CC(OC2C=CC=CC=2)=CC=1>[Cu]>[CH3:15][O:14][C:11]1[CH:10]=[CH:9][C:8]([C:4]2[O:5][C:6]([CH3:7])=[CH:2][N:3]=2)=[CH:13][CH:12]=1

Participants

4

Reactant 2

HCID 246701,1'-Biphenyl, mixt. with 1,1'-oxybis(benzene)HCID 1356214744-(4,5-Dimethyl-2-oxazolyl)phenol

Product 1

HCID 116440632-(4-Methoxyphenyl)-5-methyloxazoleYield 35.5%

Reagents, catalysts & solvents 1

HCID 23978CopperCatalyst

Procedure

2-(4-Methoxyphenyl)-5-methyloxazole was prepared in 35.5% yield of decarboxylation of the compound of part (c) with copper powder in Dowtherm at reflux temperature. The isolated product was distilled, b.p. 136°-140° C. (0.1 mm).

Workup

  1. temperatureat reflux temperature
  2. distillationThe isolated product was distilled

Sources & evidence

ORD record
ord-633c85ea63ef4eb3b73100e83b704d49
Source dataset
uspto-grants-1991_03
Patent number
US05002960

Reaction notes

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