HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzene → (2S)-2-hydroxy-4-phenylbutanenitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzene | HCID 241 | — |
| Reactant | Ethanol | HCID 702 | — |
| Reactant | 2-Hydroxy-4-phenylbutanenitrile | HCID 10909869 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Product | (2S)-2-hydroxy-4-phenylbutanenitrile | HCID 10313250 | — |
Reaction Steps
α-Cyano-3-phenylpropyl alcohol wad hydrolyzed in concentrated hydrochloric acid (0.5 ml) at room temperature for 3 days with stirring to convert it to 1-hydroxy-4-phenyl butyric acid which was isolated by crystallization from benzene. [α]D20 =7.02° (ethanol, c=0.968).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05003083 |
| Source dataset | uspto-grants-1991_03 |
| ORD ID | ord-f9a1eb9703f547199be743fe38b89c3a |
| Source note | uspto-grants-1991_03 |