反应详情

To a stirred solution of 23.5 g of 6-amino-1-hexanol and 30 g of triethylamine in 200 ml of dichloromethane, cooled in an ice bath, was added dropwise a solution of 43.3 g of p-butylbenzoyl chloride in 100 ml of dichloromethane. The mixture was allowed to stir at room temperature for 16 hours. Then the mixture was washed in succession with water, saturated sodium carbonate, water, and finally brine. The organic layer was dried over anhydrous sodium sulfate and evaporated in vacuo. The residue was triturated, filtered, and rinsed with cold hexane and gave 47.5 g of the desired product in 61% yield as a beige solid, m.p. 80°-81° C.

1. washThen the mixture was washed in succession with water, saturated sodium carbonate, water, and finally brine
2. dry with materialThe organic layer was dried over anhydrous sodium sulfate
3. customevaporated in vacuo
4. customThe residue was triturated
5. filtrationfiltered
6. washrinsed with cold hexane