反应详情

To a solution of 1.94 g of 2,4-difluoroaniline in 20 ml of toluene was added dropwise 1.29 g of phenyl chloroformate. The mixture was stirred for 15 minutes, washed with three 10 ml portions of water, dried over anhydrous sodium sulfate, and filtered through a pad of diatomaceous earth. The filtrate was evaporated in vacuo to give an oil which solidified on cooling. The solid was crystallized from hexane to give 1.73 g of the desired product as pale tan crystals in 93% yield, mp 82°-84° C.

1. washwashed with three 10 ml portions of water
2. dry with materialdried over anhydrous sodium sulfate
3. filtrationfiltered through a pad of diatomaceous earth
4. customThe filtrate was evaporated in vacuo
5. customto give an oil which
6. temperatureon cooling
7. customThe solid was crystallized from hexane