Potassium Chloride → HCID 15137712, compound

HRID 359991Notes

Reaction equation

HRID 359991 reaction equation
[CH2:1]([C:5]1[CH:10]=[CH:9][C:8]([CH2:11][N:12]([CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30]OS(C)(=O)=O)[C:13]([NH:15][C:16]2[C:21]([Cl:22])=[CH:20][C:19]([Cl:23])=[CH:18][C:17]=2[Cl:24])=[O:14])=[CH:7][CH:6]=1)[CH2:2][CH2:3][CH3:4].[Cl-:36].[K+]>CS(C)=O>[CH2:1]([C:5]1[CH:10]=[CH:9][C:8]([CH2:11][N:12]([CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][Cl:36])[C:13]([NH:15][C:16]2[C:21]([Cl:22])=[CH:20][C:19]([Cl:23])=[CH:18][C:17]=2[Cl:24])=[O:14])=[CH:7][CH:6]=1)[CH2:2][CH2:3][CH3:4]

Participants

4

Reactant 2

HCID 4873Potassium ChlorideHCID 15137706HCID 15137706, compound

Product 1

HCID 15137712HCID 15137712, compoundYield 64.7%

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

A mixture of 1.9 g of 1-[(4-butylphenyl)methyl]-1-[6-[(methylsulfonyl)oxy]hexyl]-3-(2,4,6-trichlorophenyl)urea, 0.6 g of potassium chloride, and 3.0 ml of dried dimethyl sulfoxide was heated at an oil bath temperature of 60°-70° C. for 20 hours. The extraction and chromatography procedures of Example 521 were followed to give 1.1 g of the desired product as a colorless oil.

Workup

  1. temperaturewas heated at an oil bath temperature of 60°-70° C. for 20 hours
  2. extractionThe extraction and chromatography procedures of Example 521

Sources & evidence

ORD record
ord-46709bbc712c497ab10aec2d5d213456
Source dataset
uspto-grants-1991_03
Patent number
US05003106

Reaction notes

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