Ammonium Hydroxide → 4-Butylbenzamide

HRID 359993Notes

Reaction equation

HRID 359993 reaction equation
[CH2:1]([C:5]1[CH:13]=[CH:12][C:8]([C:9](Cl)=[O:10])=[CH:7][CH:6]=1)[CH2:2][CH2:3][CH3:4].[OH-].[NH4+:15]>>[CH2:1]([C:5]1[CH:13]=[CH:12][C:8]([C:9]([NH2:15])=[O:10])=[CH:7][CH:6]=1)[CH2:2][CH2:3][CH3:4]

Participants

3

Reactant 2

HCID 14923Ammonium HydroxideHCID 1200494-Butylbenzoyl chloride

Product 1

HCID 28014584-ButylbenzamideYield 99%

Procedure

To a stirred solution of 200 ml of aqueous ammonium hydroxide was added dropwise 35 ml of 4-butylbenzoyl chloride. The resulting mixture was stirred at room temperature for several hours. The white solid was collected by filtration, washed with water, then hexane, and dried in vacuo at 60° C. to give 33.4 g (99% yield) of the desired product, mp 135°-136° C.

Workup

  1. filtrationThe white solid was collected by filtration
  2. washwashed with water
  3. dry with materialhexane, and dried in vacuo at 60° C.

Sources & evidence

ORD record
ord-db0fba08642943098ae12ac99a4f0ced
Source dataset
uspto-grants-1991_03
Patent number
US05003106

Reaction notes

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