Hydrochloric Acid → 5'-Methyl-4'-methylenespiro[1-azabicyclo[2,2,2]-octane-3,2'-thiolane]

HRID 36009Notes

Reaction equation

[CH3:1][CH:2]1[S:6][C:5]2([CH:11]3[CH2:12][CH2:13][N:8]([CH2:9][CH2:10]3)[CH2:7]2)[CH2:4][C:3]1=O.Cl.[CH2:16](O)C>>[CH3:1][CH:2]1[S:6][C:5]2([CH:11]3[CH2:12][CH2:13][N:8]([CH2:9][CH2:10]3)[CH2:7]2)[CH2:4][C:3]1=[CH2:16]

Participants

Reactant 3

HCID 313Hydrochloric Acid2×

HCID 702Ethanol

HCID 148520585'-Methylspiro[1-azabicyclo[2,2,2]-octane-3,2'-thiolan]-4'-one

Product 1

HCID 148520645'-Methyl-4'-methylenespiro[1-azabicyclo[2,2,2]-octane-3,2'-thiolane]

Procedure

5'-Methyl-4'-methylenespiro[1-azabicyclo[2,2,2]-octane-3,2'-thiolane] was prepared in much the same manner as in Example 5 by using 5'-methylspiro[1-azabicyclo[2,2,2]-octane-3,2'-thiolan]-4'-one. It was dissolved in ethanol, and then convereted to hydrochloride by addition of ethanolic hydrogen chloride.

Sources & evidence

ORD record: ord-bc539b81e42a47eb825573eae9c87b56
Source dataset: uspto-grants-1995_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05412096

Reaction notes

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