Hydrochloric Acid → HCID 19939835, compound

HRID 36021Notes

Reaction equation

HRID 36021 reaction equation
[Cl:1][C:2]1[N:11]=[C:10]2[C:5]([C:6](=[O:23])[C:7]([C:18]([O:20]CC)=[O:19])=[CH:8][N:9]2[C:12]2[C:16]([CH3:17])=[N:15][O:14][N:13]=2)=[CH:4][C:3]=1[F:24].Cl.O>C(O)(=O)C>[Cl:1][C:2]1[N:11]=[C:10]2[C:5]([C:6](=[O:23])[C:7]([C:18]([OH:20])=[O:19])=[CH:8][N:9]2[C:12]2[C:16]([CH3:17])=[N:15][O:14][N:13]=2)=[CH:4][C:3]=1[F:24]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 962WaterHCID 19939879HCID 19939879, compound

Product 1

HCID 19939835HCID 19939835, compoundYield 18.1%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Conditions

Temperature
100 °C

Procedure

Compound No. 78 (30 mg) obtained in Example 39 was dissolved in acetic acid (2 ml ) and 6N-HCl (0.5 ml). The solution was stirred at 100° C. for 0.5 hour. After cooling and addition of water (10 ml), the precipitate was filtrated and washed with ethanol and ether. The title compound No. 79 was obtained as a colorless solid (5 mg).

Workup

  1. temperatureAfter cooling
  2. filtrationthe precipitate was filtrated
  3. washwashed with ethanol and ether

Sources & evidence

ORD record
ord-69acfc675a8a426da270e4e08b402afe
Source dataset
uspto-grants-1995_05
Patent number
US05412098

Reaction notes

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