HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 36101Generated: October 29, 2026
Water → 3-Benzyl-5-cyano-2-ethyl-7-methylimidazo[4,5-b]pyridine
https://huagongshe.com/reaction/36101
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Potassium Cyanide | HCID 9032 | — |
| Reactant | 3-Benzyl-5-bromo-2-ethyl-7-methylimidazo[4,5-b]pyridine | HCID 19385661 | — |
| Reactant | HCID 178418546 | HCID 178418546 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 3-Benzyl-5-cyano-2-ethyl-7-methylimidazo[4,5-b]pyridine | HCID 19385616 | — |
Reaction Steps
A mixture of 3-benzyl-5-bromo-2-ethyl-7-methylimidazo[4,5-b]pyridine (0.62 g, 1.8 mmol) and CuCN (0.806 g, 9.0 mmol) was heated in pyridine (4 mL) at reflux for 10 h under nitrogen. The reaction was cooled, then water (50 mL), KCN (1.17 g), and EtOAc (20 mL) were added and the mixture was heated to 50° C. for 5 min. Cooling and extraction with EtOAc (2×50 mL) gave 3-benzyl-5-cyano-2-ethyl-7-methylimidazo[4,5-b]pyridine as a tan solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05412097 |
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| Source dataset | uspto-grants-1995_05 |
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| ORD ID | ord-2e74cfb894b449a7bdb6636d393adc37 |
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| Source note | uspto-grants-1995_05 |
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