反应详情

温度

50 °C

A mixture of 3-benzyl-5-bromo-2-ethyl-7-methylimidazo[4,5-b]pyridine (0.62 g, 1.8 mmol) and CuCN (0.806 g, 9.0 mmol) was heated in pyridine (4 mL) at reflux for 10 h under nitrogen. The reaction was cooled, then water (50 mL), KCN (1.17 g), and EtOAc (20 mL) were added and the mixture was heated to 50° C. for 5 min. Cooling and extraction with EtOAc (2×50 mL) gave 3-benzyl-5-cyano-2-ethyl-7-methylimidazo[4,5-b]pyridine as a tan solid.

1. temperatureat reflux for 10 h under nitrogen
2. temperatureThe reaction was cooled
3. temperatureCooling
4. extractionextraction with EtOAc (2×50 mL)