Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Iodine | HCID 807 | — |
| Reactant | 4-Bromoanisole | HCID 7730 | — |
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | Magnesium | HCID 5462224 | — |
| Product | HCID 178502596 | HCID 178502596 | — |
Reaction Steps
A suspension of magnesium turnings (268 g; 11.02 moles--Janssen) in tetrahydrofuran (2695 g) was heated at 65° C. under stirring and under nitrogen. Then, iodine (2.7 g) and, after 30 minutes, 4-bromoanisole (2000 g; 10.69 moles), in 1 hour, were added to the reaction mixture. At the end of the addition, the reaction mixture was kept at 75° C. for 1 hour and, then, decanted obtaining a solution of methoxyphenylmagnesiumbromide (solution A).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05412143 |
|---|
| Source dataset | uspto-grants-1995_05 |
|---|
| ORD ID | ord-b15b42837dcc4b9ea519390806aed125 |
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| Source note | uspto-grants-1995_05 |
|---|
