Iodine → HCID 178502596, compound

HRID 36122Notes

Reaction equation

HRID 36122 reaction equation
[Mg:1].II.[Br:4][C:5]1[CH:10]=[CH:9][C:8](OC)=[CH:7][CH:6]=1.[O:13]1[CH2:17]CCC1>>[CH3:17][O:13][Mg:1][C:5]1[CH:6]=[CH:7][CH:8]=[CH:9][CH:10]=1.[Br-:4]

Participants

5

Reactant 4

HCID 807IodineHCID 77304-BromoanisoleHCID 8028TetrahydrofuranHCID 5462224Magnesium

Product 1

HCID 178502596HCID 178502596, compound

Conditions

Temperature
65 °C

Procedure

A suspension of magnesium turnings (268 g; 11.02 moles--Janssen) in tetrahydrofuran (2695 g) was heated at 65° C. under stirring and under nitrogen. Then, iodine (2.7 g) and, after 30 minutes, 4-bromoanisole (2000 g; 10.69 moles), in 1 hour, were added to the reaction mixture. At the end of the addition, the reaction mixture was kept at 75° C. for 1 hour and, then, decanted obtaining a solution of methoxyphenylmagnesiumbromide (solution A).

Workup

  1. additionwere added to the reaction mixture
  2. additionAt the end of the addition
  3. customdecanted

Sources & evidence

ORD record
ord-b15b42837dcc4b9ea519390806aed125
Source dataset
uspto-grants-1995_05
Patent number
US05412143

Reaction notes

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