反应详情

A 500 ml single-neck flask was charged with 7-(4-methoxyphenyl)heptanoic acid (A3) (20.0 g, 90 mmole), freshly distilled 48% hydrobromic acid (80 ml), and glacial acetic acid (40 ml). The mixture was heated to reflux by immersing the flask in an oil bath regulated at 140° C. for 3.5 hours. At the end of this time, water (80 ml) was added, the flask was cooled to room temperature, and placed in the refrigerator overnight. The resulting solid, 7-(4-hydroxyphenyl)heptanoic acid, was collected by suction filtration, washed with water (2×80 ml), and dried in vacuo. The product was of sufficient purity to be used in the next step.

1. temperatureThe mixture was heated
2. temperatureto reflux
3. customplaced in the refrigerator overnight
4. filtrationThe resulting solid, 7-(4-hydroxyphenyl)heptanoic acid, was collected by suction filtration
5. washwashed with water (2×80 ml)
6. customdried in vacuo