反应详情

A 1 L three-neck flask fitted with a reflux condenser, rubber septum, addition funnel and argon inlet was charged with 200 ml of t-butanol. To the solution, n-butyl lithium (1.45N, 91.1 ml) was added dropwise using a water bath to prevent an excessive temperature rise. After stirring 30 minutes, the addition funnel was charged with p-toluoyl chloride, added dropwise. The reaction mixture was stirred overnight. At this point, the contents were transferred into a separatory funnel by using 250 ml of diethyl ether and the solution was washed with water (250 ml). The organic layer was then dried (MgSO4) and concentrated by rotary evaporation. The crude product, tert-butyl-4-toluate, was purified by fractional distillation.

1. customA 1 L three-neck flask fitted with a reflux condenser
2. additionrubber septum, addition funnel and argon inlet
3. additionadded dropwise
4. stirringThe reaction mixture was stirred overnight
5. customAt this point, the contents were transferred into a separatory funnel
6. washthe solution was washed with water (250 ml)
7. dry with materialThe organic layer was then dried (MgSO4)
8. concentrationconcentrated by rotary evaporation
9. distillationThe crude product, tert-butyl-4-toluate, was purified by fractional distillation