(1,4-Dibenzyl-1,4-diazepan-6-yl)methanol → (1,4-Diazepan-6-yl)methanol

HRID 361311Notes

Reaction equation

HRID 361311 reaction equation
C([N:8]1[CH2:14][CH:13]([CH2:15][OH:16])[CH2:12][N:11](CC2C=CC=CC=2)[CH2:10][CH2:9]1)C1C=CC=CC=1>CO.[Pd]>[NH:8]1[CH2:14][CH:13]([CH2:15][OH:16])[CH2:12][NH:11][CH2:10][CH2:9]1

Participants

4

Reactant 1

HCID 59101553(1,4-Dibenzyl-1,4-diazepan-6-yl)methanol

Product 1

HCID 23090161(1,4-Diazepan-6-yl)methanol

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

2.26 g (7.3 mmol) of (1,4-dibenzyl-[1,4]-diazepan-6-yl)-methanol are dissolved in 150 ml of methanol and hydrogenated at room temperature and normal pressure in the presence of 0.5 g of 10% palladium on activated charcoal. [1,4]-Diazepan-6-yl-methanol is obtained in the form of a light yellow oil by filtration and concentration of the filtrate.

Sources & evidence

ORD record
ord-7523249cc78043c3b0d631d3c5c90302
Source dataset
uspto-grants-1999_02
Patent number
US05866562

Reaction notes

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