HCID 10664064, compound → HCID 10686415, compound

HRID 361315Notes

Reaction equation

HRID 361315 reaction equation
[CH2:1]([C@H:4]1[C@:21]2(O)[C@:16](C)([CH2:17][CH2:18][C:19](=[O:23])[CH2:20]2)[C@@H:15]2[C@H:6]([C@H:7]3[C@@:11]([CH2:13][CH2:14]2)([CH3:12])[C:10](=[O:25])[CH2:9][CH2:8]3)[CH2:5]1)[C:2]#[CH:3].C([C@H]1[C@]2(O)[C@H](CCC(=O)C2)[C@@H]2[C@H]([C@H]3[C@@](CC2)(C)C(=O)CC3)C1)C#C>CC(C)=O.CCCCCC>[CH2:1]([C@H:4]1[C:21]2[C@H:16]([CH2:17][CH2:18][C:19](=[O:23])[CH:20]=2)[C@@H:15]2[C@H:6]([C@H:7]3[C@@:11]([CH2:13][CH2:14]2)([CH3:12])[C:10](=[O:25])[CH2:9][CH2:8]3)[CH2:5]1)[C:2]#[CH:3]

Participants

4

Reactant 2

HCID 10664064HCID 10664064, compoundHCID 10854804HCID 10854804, compound

Product 1

HCID 10686415HCID 10686415, compound

Reagents, catalysts & solvents 1

HCID 21880519Acetone hexaneSolvent

Procedure

Using a procedure similar to that described at Example 1 except replacing the 6β-propargyl-5α-hydroxyandrostane-3,17-dione (10) used therein with 6β-propargyl-5α-hydroxyestrane-3,17-dione (11), the title compound was prepared; 60%; m.p. 194°-195° C. (from acetone/hexane); 1H-NMR (CDCl3) δ 0.94 (s, 3H, 18-CH3), 2.73 (m, 1H), 5.94 (s, 1H, 4-H).

Sources & evidence

ORD record
ord-f965206eb15349feb8a0fc926d459296
Source dataset
uspto-grants-1999_02
Patent number
US05866558

Reaction notes

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