反应详情

A solution prepared from of 4-amino-3-pyridinol (1.10 g) and 10 ml of N,N-dimethylformamide dimethyl acetal was refluxed for 30 minutes. At the end of this time, the reaction mixture was concentrated under reduced pressure and the residue was passed over a short column of florisil, eluting with 5% methanol/ethyl acetate. The eluate was concentrated and the residue and recrystallized from ethyl acetate/pentane to afford 0.91 g of analytically pure product, m.p. 121°-123°.

1. temperaturewas refluxed for 30 minutes
2. concentrationAt the end of this time, the reaction mixture was concentrated under reduced pressure
3. washeluting with 5% methanol/ethyl acetate
4. concentrationThe eluate was concentrated
5. customthe residue and recrystallized from ethyl acetate/pentane
6. customto afford 0.91 g of analytically pure product, m.p. 121°-123°