反应详情

The product from Step D was suspended in 1:1:1 methanol/THF/water (9 ml) and lithium hydroxide hydrate (126 mg, 3.0 mmol) was added. After 16 h the volatiles were removed in vacuo and the solution was diluted with water and was washed with ethyl acetate, adding sufficient brine to disperse the emulsion. The aqueous layer was acidified with 5% KHSO4 solution and was extracted with methylene chloride which was then dried (Na2SO4) and evaporated in vacuo to give the title compound as a solid:

1. additionwas added
2. customAfter 16 h the volatiles were removed in vacuo
3. additionthe solution was diluted with water
4. washwas washed with ethyl acetate
5. additionadding sufficient brine
6. additionto disperse the emulsion
7. extractionwas extracted with methylene chloride which
8. dry with materialwas then dried (Na2SO4)
9. customevaporated in vacuo