反应详情

A mixture of 2-amino-5-cyano-6-methylpyridine (4.0 g, 30.0 mmol) and 10% Pd/C (3.08 g) in ethanol (80 mL), methanol (30 mL), concentrated HCl (6 mL) and water (10 mL) was shaken on a Parr apparatus at 60 psi for 25 h. The reaction was filtered through celite, rinsing with 1:1 ethanol/methanol and was evaporated in vacuo to a solid, which was triturated with 5:1 ethyl acetate/ethanol to give the title compound (5.95 g, 94%):

1. filtrationThe reaction was filtered through celite
2. washrinsing with 1:1 ethanol/methanol
3. customwas evaporated in vacuo to a solid, which
4. customwas triturated with 5:1 ethyl acetate/ethanol