反应详情

温度

100 °C

A stirred mixture of oxalyl chloride (30.5 ml, 0.35 mol) and α-(allylamino)-propionitrile hydrochloride (10.26 g, 70 mmol) in o-dichlorobenzene (100 ml) was heated to 100° C. for 15 h. The solvent was evaporated in vacuo and the residual black oil was purified by flash column chromatography on silica (eluting with 30% ethyl acetate hexanes) to give the title compound as a tan crystalline solid:

1. customThe solvent was evaporated in vacuo
2. customthe residual black oil was purified by flash column chromatography on silica (eluting with 30% ethyl acetate hexanes)