Dimethyl Sulfate → HCID 86753644, compound

HRID 361378Notes

Reaction equation

HRID 361378 reaction equation
[C:1]([O:5][C:6]([NH:8][C:9]1[C:14]([CH3:15])=[CH:13][CH:12]=[CH:11][N+:10]=1[O-:16])=[O:7])([CH3:4])([CH3:3])[CH3:2].[S:17]([O:22]C)([O:20][CH3:21])(=[O:19])=[O:18]>C(Cl)Cl>[CH3:21][O:20][S:17]([O-:22])(=[O:19])=[O:18].[C:1]([O:5][C:6]([NH:8][C:9]1[C:14]([CH3:15])=[CH:13][CH:12]=[CH:11][N+:10]=1[O:16][CH3:21])=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 6497Dimethyl SulfateHCID 178426683HCID 178426683, compound

Product 1

HCID 86753644HCID 86753644, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

To a stirred solution of 620 mg (0.29 mmol) of 2-t-butyloxycarbonylamino-3-methylpyridine-N-oxide in 8 mL of CH2Cl2 under Ar was added 262 μL (0.3 mmol) of dimethyl sulfate. The CH2Cl2 was allowed to evaporate under a slow stream of Ar overnight to give the title compound as a light tan solid:

Workup

  1. customto evaporate under a slow stream of Ar overnight

Sources & evidence

ORD record
ord-ae23a3f837344aa7bf5b2683f5033469
Source dataset
uspto-grants-1999_02
Patent number
US05866573

Reaction notes

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