反应详情

A mixture of 1-methyl-3,5-dinitro-2-pyridone (0.8 g, 4 mmol), tetrahydro-4H-pyran-4-one (0.4 g, 4 mmol) and ammonia solution in methanol (2.0M, 40 mL) was refluxed for 4 h. The solvent was removed in vacuo and the residue was dissolved in ethyl acetate. The soluble portion was flash chromatocraphed over silica gel (eluent: 90:10 v/v ethyl acetate-hexane) to give a yellow solid (O.376 g, 52% yield).

1. temperaturewas refluxed for 4 h
2. customThe solvent was removed in vacuo
3. dissolutionthe residue was dissolved in ethyl acetate
4. customto give a yellow solid (O