Hydrochloric Acid → HCID 67570411, compound

HRID 361559Notes

Reaction equation

HRID 361559 reaction equation
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH2:6][C@H:7]([C:9]([OH:11])=[O:10])[NH2:8].[CH2:12]=O.[ClH:14]>>[ClH:14].[S:1]1[C:2]2[CH2:6][C@H:7]([C:9]([OH:11])=[O:10])[NH:8][CH2:12][C:3]=2[CH:4]=[CH:5]1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 712FormaldehydeHCID 7111750D-2-Thienylalanine

Product 1

HCID 67570411HCID 67570411, compound

Conditions

Temperature
110 °C

Procedure

A mixture containing 87 mmol of β-2-thienyl-D-alanine, 11 ml of formaldehyde at 40% in aqueous medium, and 88 ml of 1N hydrochloric acid is heated for 2 h 30 min at 110° C., with stirring, and then at 60° C. overnight. After evaporation, the residue is taken up in ethanol and then evaporated and the expected product is recovered in the form of a solid in diethyl ether.

Workup

  1. customat 60° C.
  2. customovernight
  3. customAfter evaporation
  4. customevaporated
  5. customthe expected product is recovered in the form of a solid in diethyl ether

Sources & evidence

ORD record
ord-0a80edc2e60a4af88661a6be403d969e
Source dataset
uspto-grants-1999_02
Patent number
US05866587

Reaction notes

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