HuagongsheHuagongshe Chemistry Print Report · For research reference only
(R)-(+)-1-Phenylethyl isocyanate → (3aR*,10aS*)-9-[4-[3-((R)-1-Phenylethyl)ureido]-benzyl]-4-(phthalimidoacetyl)-2,3,3a,4,9,10a-hexahydrobenzo[b]cyclopenta[e][1,4]diazepin-10(1H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (R)-(+)-1-Phenylethyl isocyanate | HCID 7018262 | — |
| Reactant | (3aR*,10aS*)-9-(4-aminobenzyl)-4-(phthalimidoacetyl)-2,3,3a,4,9,10a-hexahydrobenzo[b]cyclopenta[e][l,4]diazepin-10(1H)-one | HCID 54523300 | — |
| Solvent | Diethylether ethylacetate | HCID 21584169 | — |
| Product | (3aR*,10aS*)-9-[4-[3-((R)-1-Phenylethyl)ureido]-benzyl]-4-(phthalimidoacetyl)-2,3,3a,4,9,10a-hexahydrobenzo[b]cyclopenta[e][1,4]diazepin-10(1H)-one | HCID 9917431 | 54% |
Reaction Steps
Using (3aR*,10aS*)-9-(4-aminobenzyl)-4-(phthalimidoacetyl)-2,3,3a,4,9,10a-hexahydrobenzo[b]cyclopenta[e][1,4]diazepin-10(1H)-one and (R)-1-phenylethyl isocyanate, the title compound was synthesized in otherwise the same manner as Example 26. Yield 54%, m.p. 158°-163° C. (ethyl acetate-diethyl ether).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05866567 |
| Source dataset | uspto-grants-1999_02 |
| ORD ID | ord-4636ea6261ea4bc0a0eef21e01f9c8e5 |
| Source note | uspto-grants-1999_02 |