Diethyl ether ethanol → HCID 54563692, compound

HRID 361586Notes

Reaction equation

ClCC([N:5]1[C@@H:11]2[CH2:12][CH2:13][CH2:14][C@@H:10]2[C:9](=[O:15])[N:8]([CH2:16][C:17]2[CH:22]=[CH:21][C:20]([NH:23][C:24]([NH:26][CH2:27][C:28]3[CH:33]=[CH:32][C:31]([F:34])=[CH:30][CH:29]=3)=[O:25])=[CH:19][CH:18]=2)[C:7]2[CH:35]=[CH:36][CH:37]=[CH:38][C:6]1=2)=O.[CH2:39]([OH:41])[CH3:40].C([O:44][CH2:45][CH3:46])C>>[F:34][C:31]1[CH:30]=[CH:29][C:28]([CH2:27][NH:26][C:24](=[O:25])[NH:23][C:20]2[CH:19]=[CH:18][C:17]([CH2:16][N:8]3[C:9](=[O:15])[C@H:10]4[CH2:14][CH2:13][CH2:12][C@H:11]4[N:5]([C:45](=[O:44])[CH2:46][N:8]4[C:39](=[O:41])[C:40]5=[CH:14][CH:13]=[CH:12][CH:11]=[C:10]5[C:9]4=[O:15])[C:6]4[CH:38]=[CH:37][CH:36]=[CH:35][C:7]3=4)=[CH:22][CH:21]=2)=[CH:33][CH:32]=1

Participants

Reactant 2

HCID 21585056Diethyl ether ethanol

HCID 86753653HCID 86753653, compound

Product 1

HCID 54563692HCID 54563692, compoundYield 35%

Procedure

Using (3aR*,10aS*)-4-(chloroacetyl)-9-[4-[3-(4-fluorobenzyl)ureido]benzyl]-2,3,3a,4,9,10a-hexahydrobenzo[b]cyclopenta[e][1,4]diazepin-10(1H)-one, the title compound was synthesized in otherwise the same manner as Example 30. Yield 35%, m.p. 154°-156° C. (ethanol-diethyl ether).

Sources & evidence

ORD record: ord-5f30dd94ee854e9c8192f4e5ee0619b3
Source dataset: uspto-grants-1999_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05866567

Reaction notes

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