HCID 54497968, compound → HCID 4738526, compound

HRID 361602Notes

Reaction equation

HRID 361602 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]1[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[CH2:10][CH2:9][N:8]=1.[H][H]>C(O)C.[Pt](=O)=O>[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH:7]1[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[CH2:10][CH2:9][NH:8]1

Participants

5

Reactant 2

HCID 54497968HCID 54497968, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 4738526HCID 4738526, compoundYield 108.9%

Reagents, catalysts & solvents 2

HCID 345198Adams' catalystCatalystHCID 702EthanolSolvent

Procedure

A solution of 6.1 g of 1-pyridin-2-yl-3,4-dihydro-isoquinoline in 220 ml of absolute ethanol was hydrogenated on 1.25 g of platinum dioxide at 20° C. and 1 bar hydrogen pressure for 90 min. After removal of the catalyst by filtration, [the filtrate] was concentrated under reduced pressure. There were obtained 6.71 g of (RS)-1-pyridin-2-yl-1,2,3,4-tetrahydro-isoquinoline as a colorless oil, b.p. 140° C./0.1 mbar (bulb-tube).

Workup

  1. customAfter removal of the catalyst
  2. filtrationby filtration
  3. concentration[the filtrate] was concentrated under reduced pressure

Sources & evidence

ORD record
ord-ac3aa594303843d4bb51aa36db8e8a03
Source dataset
uspto-grants-1999_02
Patent number
US05866583

Reaction notes

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