Hydrogen Peroxide → HCID 54231101, compound

HRID 361626Notes

Reaction equation

HRID 361626 reaction equation
[CH3:1][C:2]1[CH:10]=[CH:9][C:8]([CH3:11])=[C:7]2[C:3]=1[CH2:4][CH:5]([C:12]([O:14][CH3:15])=[O:13])[NH:6]2.[OH:16]O>CO>[OH:16][N:6]1[C:7]2[C:3](=[C:2]([CH3:1])[CH:10]=[CH:9][C:8]=2[CH3:11])[CH:4]=[C:5]1[C:12]([O:14][CH3:15])=[O:13]

Participants

4

Reactant 2

HCID 784Hydrogen PeroxideHCID 54118280HCID 54118280, compound

Product 1

HCID 54231101HCID 54231101, compoundYield 35.5%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
0 °C

Procedure

A flask was charged with 1.0 g (4.9 mmol) of methyl 4,7-dimethylindoline-2-carboxylate and 64 mg (0.193 mmol) of sodium tungstate-dihydrate, and the air in the reaction system was substituted with nitrogen. Methanol (15 ml) was added and the reaction mixture was cooled to 0° C. Then 1.25 g of 30% aqueous hydrogen peroxide solution was added and the reaction mixture was stirred for 3 hours. Yield: 35.5%

Sources & evidence

ORD record
ord-50c2b3df7b494567b895aac7e072122a
Source dataset
uspto-grants-1999_02
Patent number
US05866594

Reaction notes

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