Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 361636Generated: October 31, 2026

Hydrochloric Acid → HCID 178479496, compound

https://huagongshe.com/reaction/361636

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHydrochloric AcidHCID 313—
ReactantPhenolHCID 996—
ReactantPotassium CarbonateHCID 11430—
ReactantHCID 178513061HCID 178513061—
SolventDimethylformamideHCID 6228—
SolventDichloromethane methanolHCID 21226129—
ProductHCID 178479496HCID 178479496—

Reaction Steps

Colorless crystals, m.p. 162°-65° C. from 4-fluoro-3-trifluoromethylbenzoylguanidine (30 base) by reaction with phenol in the presence of potassium carbonate in DMF at 120° C., aqueous work-up, column chromatography, methylene chloride/methanol 9:1, followed by hydrochloride formation

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05866610
Source datasetuspto-grants-1999_02
ORD IDord-0f32911dda264704a664905fa675b10e
Source noteuspto-grants-1999_02