Hydrochloric Acid → HCID 178479496, compound

HRID 361636Notes

Reaction equation

HRID 361636 reaction equation
F[C:2]1[CH:13]=[CH:12][C:5]([C:6]([NH:8][C:9]([NH2:11])=[NH:10])=[O:7])=[CH:4][C:3]=1[C:14]([F:17])([F:16])[F:15].[C:18]1([OH:24])[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1.C(=O)([O-])[O-].[K+].[K+].[ClH:31]>CN(C=O)C.C(Cl)Cl.CO>[ClH:31].[O:24]([C:2]1[CH:13]=[CH:12][C:5]([C:6]([NH:8][C:9]([NH2:11])=[NH:10])=[O:7])=[CH:4][C:3]=1[C:14]([F:17])([F:16])[F:15])[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1

Participants

7

Reactant 4

HCID 313Hydrochloric AcidHCID 996PhenolHCID 11430Potassium CarbonateHCID 178513061HCID 178513061, compound

Product 1

HCID 178479496HCID 178479496, compound

Reagents, catalysts & solvents 2

HCID 6228DimethylformamideSolventHCID 21226129Dichloromethane methanolSolvent

Procedure

Colorless crystals, m.p. 162°-65° C. from 4-fluoro-3-trifluoromethylbenzoylguanidine (30 base) by reaction with phenol in the presence of potassium carbonate in DMF at 120° C., aqueous work-up, column chromatography, methylene chloride/methanol 9:1, followed by hydrochloride formation

Sources & evidence

ORD record
ord-0f32911dda264704a664905fa675b10e
Source dataset
uspto-grants-1999_02
Patent number
US05866610

Reaction notes

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