反应详情

A mixture of N-[3-(4-benzyloxyphenoxy)propyl]phthalimide (3.87 g) and hydrazine hydrate (0.55 g) in ethanol (40 ml) was heated at reflux for 3 hours. The reaction mixture was allowed to cool, filtered and the filtrate evaporated. Sodium hydroxide solution (2M, 20 ml) was added to the residue, the aqueous mixture extracted with ethyl acetate and the ethyl acetate extract dried. The solid collected by filtration of the cooled reaction mixture was suspended in sodium hydroxide solution (2M, 20 ml) and extracted with ethyl acetate. The ethyl acetate extract was dried, combined with the dried ethyl acetate derived from the filtrate and the combined extract evaporated to give 3-(4-benzyloxyphenoxy)propylamine as a solid (1.5 g), m.p. 115° C.

1. temperaturewas heated
2. temperatureat reflux for 3 hours
3. temperatureto cool
4. filtrationfiltered
5. customthe filtrate evaporated
6. additionSodium hydroxide solution (2M, 20 ml) was added to the residue
7. extractionthe aqueous mixture extracted with ethyl acetate
8. extractionthe ethyl acetate extract
9. customdried
10. filtrationThe solid collected by filtration of the cooled reaction mixture
11. extractionextracted with ethyl acetate
12. extractionThe ethyl acetate extract
13. customwas dried
14. extractionthe combined extract
15. customevaporated