Sodium Hydroxide → HCID 131721104, compound

HRID 361756Notes

Reaction equation

HRID 361756 reaction equation
[OH-:1].[Na+:2].[O:3]1[CH:7]=[CH:6][C:5]([CH:8]2[NH:11][C:10](=[O:12])[C:9]2([CH3:14])[CH3:13])=[CH:4]1>O1CCCC1>[Na+:2].[O:3]1[CH:7]=[CH:6][C:5]([CH:8]([C:9]([CH3:14])([CH3:13])[C:10]([O-:1])=[O:12])[NH2:11])=[CH:4]1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 54117524HCID 54117524, compound

Product 1

HCID 131721104HCID 131721104, compoundYield 94.6%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Sodium hydroxide (378 mg, 9.45 mmol) and tetrahydrofuran (10 ml) were added to 4-(3-furyl)-3,3-dimethyl-2-azetidinone (1.2 g, 7.21 mmol) and the mixture was refluxed for 8 hours. After the solvent was distilled off, the residue was washed with ethyl acetate to give a powder of β-(3-furyl)-α,α-dimethyl-β-alanine sodium salt (1.4 g, quant.).

Workup

  1. temperaturethe mixture was refluxed for 8 hours
  2. distillationAfter the solvent was distilled off
  3. washthe residue was washed with ethyl acetate

Sources & evidence

ORD record
ord-29966f1af1d7479882cd0fb5e15342e5
Source dataset
uspto-grants-1999_02
Patent number
US05866592

Reaction notes

Loading…