Piperidin-4-ol → HCID 10650245, compound

HRID 361769Notes

Reaction equation

HRID 361769 reaction equation
[CH2:1]([O:3][C:4](=[O:32])[CH2:5][CH:6]1[CH2:11][CH2:10][N:9]([C:12](=[O:31])[C:13]([CH3:30])([CH3:29])[CH:14]([CH2:27][CH3:28])[NH:15][C:16](=[O:26])[C:17]2[CH:22]=[CH:21][C:20]([C:23]#[N:24])=[CH:19][C:18]=2[F:25])[CH2:8][CH2:7]1)[CH3:2].[OH:33][CH:34]1[CH2:39][CH2:38][NH:37][CH2:36][CH2:35]1>>[CH2:1]([O:3][C:4](=[O:32])[CH2:5][CH:6]1[CH2:7][CH2:8][N:9]([C:12](=[O:31])[C:13]([CH3:30])([CH3:29])[CH:14]([CH2:27][CH3:28])[NH:15][C:16](=[O:26])[C:17]2[CH:22]=[CH:21][C:20]([C:23]([N:37]3[CH2:38][CH2:39][CH:34]([OH:33])[CH2:35][CH2:36]3)=[NH:24])=[CH:19][C:18]=2[F:25])[CH2:10][CH2:11]1)[CH3:2]

Participants

3

Reactant 2

HCID 79341Piperidin-4-olHCID 85172428HCID 85172428, compound

Product 1

HCID 10650245HCID 10650245, compoundYield 26%

Procedure

The same procedure as in Example 45 was performed with ethyl-N-(N-(4-cyano-2-fluorobenzoyl)-β-ethyl-α,α-dimethyl-β-alanyl)-4-piperidineacetate (1.4 g, 3.1 mmol) by using 4-hydroxypiperidine (3.1 g) as an amine to yield the titled compound (440 mg, 26%).

Sources & evidence

ORD record
ord-0eaa0a51450a4be18b5f340a467368df
Source dataset
uspto-grants-1999_02
Patent number
US05866592

Reaction notes

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