1-(4-Fluorophenyl)piperazine → HCID 10794013, compound

HRID 361773Notes

Reaction equation

HRID 361773 reaction equation
[CH2:1]([O:3][C:4](=[O:32])[CH2:5][CH:6]1[CH2:11][CH2:10][N:9]([C:12](=[O:31])[C:13]([CH3:30])([CH3:29])[CH:14]([CH2:27][CH3:28])[NH:15][C:16](=[O:26])[C:17]2[CH:22]=[CH:21][C:20]([C:23]#[N:24])=[CH:19][C:18]=2[F:25])[CH2:8][CH2:7]1)[CH3:2].[F:33][C:34]1[CH:39]=[CH:38][C:37]([N:40]2[CH2:45][CH2:44][NH:43][CH2:42][CH2:41]2)=[CH:36][CH:35]=1>>[CH2:1]([O:3][C:4](=[O:32])[CH2:5][CH:6]1[CH2:7][CH2:8][N:9]([C:12](=[O:31])[C:13]([CH3:30])([CH3:29])[CH:14]([CH2:27][CH3:28])[NH:15][C:16](=[O:26])[C:17]2[CH:22]=[CH:21][C:20]([C:23]([N:43]3[CH2:42][CH2:41][N:40]([C:37]4[CH:36]=[CH:35][C:34]([F:33])=[CH:39][CH:38]=4)[CH2:45][CH2:44]3)=[NH:24])=[CH:19][C:18]=2[F:25])[CH2:10][CH2:11]1)[CH3:2]

Participants

3

Reactant 2

HCID 752601-(4-Fluorophenyl)piperazineHCID 85172428HCID 85172428, compound

Product 1

HCID 10794013HCID 10794013, compoundYield 19.2%

Procedure

The same procedure as in Example 45 was performed with ethyl-N-(N-(4-cyano-2-fluorobenzoyl)-β-ethyl-α,α-dimethyl-β-alanyl)-4-piperidineacetate (1.48 g, 3.3 mmol) by using 1-(4-fluorophenyl) piperazine (5.9 g) as an amine to yield the titled compound (396 mg, 19%).

Sources & evidence

ORD record
ord-dfde9f2efe5e440da7a50e10a2b5b1e9
Source dataset
uspto-grants-1999_02
Patent number
US05866592

Reaction notes

Loading…