HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Benzyl-4-[N-ethyl-N-(3-(formyl)-2-pyridinyl)amino]piperidine → 1-Benzyl-4-(N-ethyl-N-(3-(1-propenyl)-2-pyridinyl)amino)piperidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Benzyl-4-[N-ethyl-N-(3-(formyl)-2-pyridinyl)amino]piperidine | HCID 10782193 | — |
| Reactant | Butyllithium | HCID 178418339 | — |
| Catalyst | Phosphonium, ethyltriphenyl-, bromide (1:1) | HCID 73727 | — |
| Product | 1-Benzyl-4-(N-ethyl-N-(3-(1-propenyl)-2-pyridinyl)amino)piperidine | HCID 54199836 | — |
Reaction Steps
Following the general procedure of EXAMPLE 14 and making non-critical variations but starting with n-butyl lithium (1.6M, 1.16 ml, 1.86 mmol), ethyltriphenylphosphonium bromide (0.69 g, 1.86 mmol), and 1-benzyl-4-[N-ethyl-N-(3-(formyl)-2-pyridinyl)amino]piperidine (XXI, EXAMPLE 12, 0.40 g, 1.24 mmol), the title compound is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05866589 |
| Source dataset | uspto-grants-1999_02 |
| ORD ID | ord-eae86cf9cbf84a07b92d62a54ae33036 |
| Source note | uspto-grants-1999_02 |