1-Benzyl-4-[N-ethyl-N-(3-(formyl)-2-pyridinyl)amino]piperidine → HCID 54199836, compound

HRID 361796Notes

Reaction equation

HRID 361796 reaction equation
[CH2:1]([Li])[CH2:2]CC.[CH2:6]([N:13]1[CH2:18][CH2:17][CH:16]([N:19]([CH2:28][CH3:29])[C:20]2[C:25]([CH:26]=O)=[CH:24][CH:23]=[CH:22][N:21]=2)[CH2:15][CH2:14]1)[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1>[Br-].C([P+](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)C>[CH2:6]([N:13]1[CH2:18][CH2:17][CH:16]([N:19]([CH2:28][CH3:29])[C:20]2[C:25]([CH:26]=[CH:1][CH3:2])=[CH:24][CH:23]=[CH:22][N:21]=2)[CH2:15][CH2:14]1)[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1

Participants

4

Reactant 2

HCID 107821931-Benzyl-4-[N-ethyl-N-(3-(formyl)-2-pyridinyl)amino]piperidineHCID 178418339Butyllithium

Product 1

HCID 54199836HCID 54199836, compound

Reagents, catalysts & solvents 1

HCID 73727Phosphonium, ethyltriphenyl-, bromide (1:1)Catalyst

Procedure

Following the general procedure of EXAMPLE 14 and making non-critical variations but starting with n-butyl lithium (1.6M, 1.16 ml, 1.86 mmol), ethyltriphenylphosphonium bromide (0.69 g, 1.86 mmol), and 1-benzyl-4-[N-ethyl-N-(3-(formyl)-2-pyridinyl)amino]piperidine (XXI, EXAMPLE 12, 0.40 g, 1.24 mmol), the title compound is obtained.

Sources & evidence

ORD record
ord-eae86cf9cbf84a07b92d62a54ae33036
Source dataset
uspto-grants-1999_02
Patent number
US05866589

Reaction notes

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