HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chloro-3-nitropyridine → 1-Benzyl-4-[N-(1-methylethyl)-N-(3-nitro-2-pyridinyl)amino]piperidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chloro-3-nitropyridine | HCID 79613 | — |
| Reactant | 1-benzyl-N-methylpiperidin-4-amine | HCID 4136128 | — |
| Reactant | 2-Bromo-3-ethoxypyridine | HCID 10631926 | — |
| Product | 1-Benzyl-4-[N-(1-methylethyl)-N-(3-nitro-2-pyridinyl)amino]piperidine | HCID 10736856 | — |
Reaction Steps
Following the general procedure of EXAMPLE 70, and making non-critical variations but substituting 1-benzyl-4-(1-methylethylamino)piperidine (EXAMPLE 99) for 1-benzyl-4-(methylamino)piperidine and 2-chloro-3-nitropyridine for 2-bromo-3-ethoxypyridine and using a reaction time of 2 hrs, the title compound is obtained, NMR (CDCl3) 8.24, 7.90, 7.31-7.23, 6.62, 3.61, 3.49, 2.97, 2.27, 1.96, 1.77 and 1.39δ.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05866589 |
| Source dataset | uspto-grants-1999_02 |
| ORD ID | ord-e2fd34e68bf847748ad308344ac0f9c4 |
| Source note | uspto-grants-1999_02 |