Acetaldehyde → 1-benzyl-4-[N-ethyl-N-(3-(isopropylamino)-2-pyridinyl)amino]piperidine

HRID 361829Notes

Reaction equation

HRID 361829 reaction equation
[CH2:1]([N:8]1[CH2:13][CH2:12][CH:11]([N:14]([CH2:22][CH2:23]C)[C:15]2[C:20]([NH2:21])=[CH:19][CH:18]=[CH:17][N:16]=2)[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(=O)C.[CH3:28][C:29]([CH3:31])=O>>[CH2:1]([N:8]1[CH2:13][CH2:12][CH:11]([N:14]([CH2:22][CH3:23])[C:15]2[C:20]([NH:21][CH:29]([CH3:31])[CH3:28])=[CH:19][CH:18]=[CH:17][N:16]=2)[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 3

HCID 177AcetaldehydeHCID 180AcetoneHCID 105680191-Benzyl-4-[N-propyl-N-(3-amino-2-pyridinyl)amino]piperidine

Product 1

HCID 106893571-benzyl-4-[N-ethyl-N-(3-(isopropylamino)-2-pyridinyl)amino]piperidine

Procedure

Following the general procedure of EXAMPLE 115 and making non-critical variations but substituting 1-benzyl-4-[N-ethyl-N-(3-amino-2-pyridinyl)amino]piperidine (PREPARATION 4) for 1-benzyl-4-[N-propyl-N-(3-amino-2-pyridinyl)amino]piperidine and acetone for acetaldehyde, the title compound is obtained, NMR (CDCl3) 7.71, 7.30, 7.25, 6.80, 4.72, 3.55, 3.50, 3.11, 3.00, 2.88, 2.00, 1.74, 1.66, 1.20 and 0.86δ.

Sources & evidence

ORD record
ord-5a79f2b68c794c5fa3ce13273714cb61
Source dataset
uspto-grants-1999_02
Patent number
US05866589

Reaction notes

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