HCID 53819161, compound → HCID 67576821, compound

HRID 361838Notes

Reaction equation

HRID 361838 reaction equation
C([N:8]1[CH2:13][CH2:12][CH:11]([N:14]([CH3:26])[C:15]2[CH:20]=[CH:19][C:18]([F:21])=[CH:17][C:16]=2[NH:22][CH:23]([CH3:25])[CH3:24])[CH2:10][CH2:9]1)C1C=CC=CC=1.[H][H]>C(O)C.[OH-].[Pt+2].[OH-]>[CH3:26][N:14]([CH:11]1[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]1)[C:15]1[CH:20]=[CH:19][C:18]([F:21])=[CH:17][C:16]=1[NH:22][CH:23]([CH3:25])[CH3:24]

Participants

5

Reactant 2

HCID 53819161HCID 53819161, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 67576821HCID 67576821, compound

Reagents, catalysts & solvents 2

HCID 9859412Platinum hydroxide (Pt(OH)2)CatalystHCID 702EthanolSolvent

Procedure

1-Benzyl-4-[N-methyl-N-(2-isopropylamino-4-fluorophenyl)amino]piperidine (EXAMPLE 170, 2.90 g, 8.16 mmol) and platinum hydroxide on carbon (1.0 g) in 50 ml ethanol is hydrogenated at 276 kPa (40 psi) hydrogen for 25 hrs. Filtration and evaporation of the solvent gives the tide compound, NMR (300 MHz, CD3OD) 7.02, 6.32, 6.24, 3.60, 3.15, 2.90, 2.75, 2.54, 1.8-2.0, 1.50 and 1.18δ.

Workup

  1. filtrationFiltration and evaporation of the solvent
  2. customgives the tide compound, NMR (300 MHz, CD3OD) 7.02, 6.32, 6.24, 3.60, 3.15, 2.90, 2.75, 2.54, 1.8-2.0, 1.50 and 1

Sources & evidence

ORD record
ord-ccd2a518ae5a46c88424b3b1efe9edbd
Source dataset
uspto-grants-1999_02
Patent number
US05866589

Reaction notes

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