HCID 67576838, compound → HCID 54501805, compound

HRID 361844Notes

Reaction equation

HRID 361844 reaction equation
C([N:8]1[CH2:13][CH2:12][CH:11]([CH2:14][N:15]([CH2:26][CH3:27])[C:16]2[C:21]([NH:22][CH:23]([CH3:25])[CH3:24])=[CH:20][CH:19]=[CH:18][N:17]=2)[CH2:10][CH2:9]1)C1C=CC=CC=1.[H][H]>C(O)C.[OH-].[Pt+2].[OH-]>[CH2:26]([N:15]([CH2:14][CH:11]1[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]1)[C:16]1[C:21]([NH:22][CH:23]([CH3:25])[CH3:24])=[CH:20][CH:19]=[CH:18][N:17]=1)[CH3:27]

Participants

5

Reactant 2

HCID 67576838HCID 67576838, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 54501805HCID 54501805, compound

Reagents, catalysts & solvents 2

HCID 9859412Platinum hydroxide (Pt(OH)2)CatalystHCID 702EthanolSolvent

Procedure

1-Benzyl-4-[N-ethyl-N-(3-isopropyl-2-pyridinyl)amino]methylpiperidine (EXAMPLE 178, 1.82 g, 4.97 mmol) and platinum hydroxide on carbon (675 mg) in 30 ml ethanol is hydrogenated at 40 p.s.i. hydrogen for 48 hrs. Filtration and evaporation of the solvent gives the title compound, NMR (300 MHz, CD3OD) 7.56, 6.97, 3.60, 2.94, 2.44, 1.69, 1.48, 1.20, 1.10 and 0.99δ.

Workup

  1. filtrationFiltration and evaporation of the solvent

Sources & evidence

ORD record
ord-53928660f8e0429e83f4df8b8adbe177
Source dataset
uspto-grants-1999_02
Patent number
US05866589

Reaction notes

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