HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Benzyl-4-[N-ethyl-N-(3-propylamino-2-pyridinyl)amino]piperidine → 4-[N-ethyl-N-(3-propylamino-2-pyridinyl)amino]piperidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Benzyl-4-[N-ethyl-N-(3-propylamino-2-pyridinyl)amino]piperidine | HCID 67576723 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Palladium hydroxide | HCID 9942167 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 4-[N-ethyl-N-(3-propylamino-2-pyridinyl)amino]piperidine | HCID 10825398 | — |
Reaction Steps
1-Benzyl-4-[N-ethyl-N-(3-propylamino-2-pyridinyl)amino]piperidine (EXAMPLE 191, 4.34 g, 12.3 mmol) and palladium hydroxide on carbon (2.0 g) in 50 ml ethanol is hydrogenated at 40 p.s.i. hydrogen for 40 hr. Filtration and removal of the solvent gives the title compound, NMR (400 MHz, CDCl3) 7.72, 6.95, 6.83, 3.72, 3.42, 3.09, 2.87, 2.00, 1.66, 1.24, 1.00 and 0.87δ.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05866589 |
| Source dataset | uspto-grants-1999_02 |
| ORD ID | ord-cc6f629da7a14fefb33ddcb47bf6452b |
| Source note | uspto-grants-1999_02 |