反应详情

N-Benzyloxycarbonyl-O-(2-methoxyethoxymethyl)ethanolamine (6.25 g, 22.0 mmol) was dissolved in ethanol (10 ml) and placed under a blanket of argon. A slurry of 10% palladium on charcoal (1 g) in ethyl acetate was added and hydrogen gas was bubbled through the suspension for 3 hours and then the mixture was placed under hydrogen atmosphere overnight. TLC indicated that some starting material still remained so a further batch ofcatalyst (1 g) was added and hydrogenation was allowed to continue for a further 6 hours, after which all the starting material had been consumed. The catalyst was removed by filtration and the filtrate was used directly in Example 1 h (product volatile).

1. customhydrogen gas was bubbled through the suspension for 3 hours
2. additionwas added
3. waitto continue for a further 6 hours
4. customafter which all the starting material had been consumed
5. customThe catalyst was removed by filtration
6. customwas used directly in Example 1 h (product volatile)