HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → L-tert-Leucine-N-2-(2-methoxy-ethoxymethoxy)ethylamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | N-Benzyloxycarbonyl-L-tert-leucine-N-2-(2-methoxy-ethoxymethoxy)ethylamide | HCID 22942185 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | L-tert-Leucine-N-2-(2-methoxy-ethoxymethoxy)ethylamide | HCID 22942183 | — |
Reaction Steps
N-Benzyloxycarbonyl-L-tert-leucine-N-2-(2-methoxy-ethoxymethoxy)ethylamide was deprotected by hydrogenolysis, as described in Step G. Reaction was complete after 3 hours, leaving a single ninhydrin positive spot on TLC (5% methanol in dichloromethane). The solvent wwas removed to give the title compound as a white foam. Yield: 1.17 9(92%). 1H--NMR; δCD3OD), 4.66 (2H, s), 3.68-3.48 (7H, br m), 3.40 (1H, m), 3.35 (3H, s) and 0.95 (9H, s).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05866717 |
| Source dataset | uspto-grants-1999_02 |
| ORD ID | ord-b3e03c7e2d224857a1b01388bb5a988b |
| Source note | uspto-grants-1999_02 |