Water → 4-[(4-Hydroxy-3-methylphenyl)methyl]-2,5-dimethylphenol

Temperature

20 °C

Into a 1 liter of four-necked flask were charged 4.76 g of para-toluenesulfonic acid, 54.07 g of ortho-cresol and 108.14 g of methanol. Further, keeping the temperature at 30° C., 38.05 g of 4-hydroxymethyl-2,5-dimethylphenol obtained above was added in ten portions over 1 hour. The mixture was stirred at the same temperature for 2 more hours. After completion of the reaction, 200 g of toluene and 200 gof ethyl acetate was added. Thereafter, 200 g of deionized water was added and the resulting mixture was stirred and a phase separation was carried out. Then, metal content was removed by adding 200 g of 1% aqueous oxalic acid solution, followed by stirring the mixture and by carrying out a phase separation. Thereafter, washing with 200 g of deionized water was repeated four times, and the oil phase was concentrated. To the concentrated mass, 200 g of toluene was added and the resulting solution was cooled to 20° C. and filtered. The filter cake was rinsed with 200 g of toluene and dissolved in 200 g of ethyl acetate. After adding 200g of toluene thereto, the resulting mixture was concentrated. To the concentrated mass, 200 g of toluene was added and the resulting mass was cooled to 20° C. and filtered. The filter cake was rinsed with 200 g of toluene and dried a whole day and night under reduced pressure at 45° C. to obtain 20.12 g of 4-(4-hydroxy-3-methylbenzyl)-2,5-dimethylphenol.

1. additionabove was added in ten portions over 1 hour
2. additionwas added
3. stirringthe resulting mixture was stirred
4. customa phase separation
5. customThen, metal content was removed
6. additionby adding 200 g of 1% aqueous oxalic acid solution
7. stirringby stirring the mixture
8. customa phase separation
9. washThereafter, washing with 200 g of deionized water
10. concentrationthe oil phase was concentrated
11. additionTo the concentrated mass, 200 g of toluene was added
12. filtrationfiltered
13. washThe filter cake was rinsed with 200 g of toluene
14. dissolutiondissolved in 200 g of ethyl acetate
15. additionAfter adding 200g of toluene
16. concentrationthe resulting mixture was concentrated
17. additionTo the concentrated mass, 200 g of toluene was added
18. temperaturethe resulting mass was cooled to 20° C.
19. filtrationfiltered
20. washThe filter cake was rinsed with 200 g of toluene
21. customdried a whole day and night under reduced pressure at 45° C.

ORD record

ord-52e4616b62134c6bb77c5aa1c478292e

Source dataset

uspto-grants-1999_02

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US05866724