HRID362028

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID62493

2,2-Dimethylpropanoyl chloride

C5H9ClO

结构：COc1ccc(CS[C@H]2C[C@@H](C(=O)O)N(C(=O)OCc3ccc([N+](=O)[O-])cc3)C2)cc1

HCID15297071

未命名化合物

结构：C[C@@H]1CN(C(=O)OCc2ccc([N+](=O)[O-])cc2)[C@@H](C)CN1

HCID67586047

未命名化合物

PRODUCTS

生成物

结构：C[C@@H]1CN(C(=O)[C@@H]2C[C@H](S)CN2C(=O)OCc2ccc([N+](=O)[O-])cc2)[C@@H](C)CN1C(=O)OCc1ccc([N+](=O)[O-])cc1

HCID86751994

未命名化合物

收率 23.9%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID8471

Triethylamine

C6H15N

PROCEDURE

实验过程

Following a procedure similar to that described in Preparation 8, but using 1.79 g of (2S,4S)-4-(4-methoxybenzylthio)-1-(4-nitrobenzyloxycarbonyl)-2-pyrrolidinecarboxylic acid, 0.54 ml of pivaloyl chloride, 0.61 ml of triethylamine and 1.29 g of trans-2,5-dimethyl-1-(4-nitrobenzyloxycarbonyl)piperazine, 577 mg of the title compound were obtained as an amorphous solid.

WORKUP

后处理

customthat described in Preparation 8

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-e1ecb8764e9348d29b94c61f0e9743c3
来源数据集: uspto-grants-1999_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05866564
来源说明: uspto-grants-1999_02

反应 SMILES

COC1C=CC(C[S:8][C@@H:9]2[CH2:13][N:12]([C:14]([O:16][CH2:17][C:18]3[CH:23]=[CH:22][C:21]([N+:24]([O-:26])=[O:25])=[CH:20][CH:19]=3)=[O:15])[C@H:11]([C:27]([OH:29])=O)[CH2:10]2)=CC=1.C(Cl)(=O)C(C)(C)C.[CH3:39][C@H:40]1[CH2:45][NH:44][C@H:43]([CH3:46])[CH2:42][N:41]1[C:47]([O:49][CH2:50][C:51]1[CH:56]=[CH:55][C:54]([N+:57]([O-:59])=[O:58])=[CH:53][CH:52]=1)=[O:48]>C(N(CC)CC)C>[CH3:46][C@H:43]1[CH2:42][N:41]([C:47]([O:49][CH2:50][C:51]2[CH:56]=[CH:55][C:54]([N+:57]([O-:59])=[O:58])=[CH:53][CH:52]=2)=[O:48])[C@H:40]([CH3:39])[CH2:45][N:44]1[C:27]([C@@H:11]1[CH2:10][C@H:9]([SH:8])[CH2:13][N:12]1[C:14]([O:16][CH2:17][C:18]1[CH:19]=[CH:20][C:21]([N+:24]([O-:26])=[O:25])=[CH:22][CH:23]=1)=[O:15])=[O:29]