Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2,2-Dimethylpiperazine → (2S,4S)-2-[3,3-Dimethyl-4-(4-nitrobenzyloxycarbonyl)-1-piperazinylcarbonyl]-4-mercapto-1-(4-nitrobenzyloxycarbonyl)pyrrolidine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2,2-Dimethylpiperazine | HCID 14664186 | — |
| 반응물 | (2S,4S)-4-(4-methoxybenzyl)thio-1-(4-nitrobenzyloxycarbonyl)-L-proline | HCID 15297071 | — |
| 생성물 | (2S,4S)-2-[3,3-Dimethyl-4-(4-nitrobenzyloxycarbonyl)-1-piperazinylcarbonyl]-4-mercapto-1-(4-nitrobenzyloxycarbonyl)pyrrolidine | HCID 88319373 | 106% |
반응 단계
Following a procedure similar to that described in Preparation 38, but using 0.35 g of (2S,4S)-4-(4-methoxybenzylthio)-1-(4-nitrobenzyloxycarbonyl)-2-pyrrolidinecarboxylic acid, 0.15 g of N,N'-carbonyldiimidazole and 0.13 g of 2,2-dimethylpiperazine, 250 mg of the title compound were obtained as an amorphous solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05866564 |
| 출처 데이터셋 | uspto-grants-1999_02 |
| ORD ID | ord-4c708044b26c4799bd842852fec35648 |
| 출처 메모 | uspto-grants-1999_02 |