Hydrochloric Acid → HCID 178465582, compound

HRID 362098Notes

Reaction equation

HRID 362098 reaction equation
[C:1]([NH:4][CH:5]1[CH2:8][N:7]([C:9]([C@@H:11]2[CH2:15][C@H:14]([S:16][C:17]3[C@H:18]([CH3:31])[C@@H:19]4[C@@H:26]([C@H:27]([OH:29])[CH3:28])[C:25](=[O:30])[N:20]4[C:21]=3[C:22]([OH:24])=[O:23])[CH2:13][NH:12]2)=[O:10])[CH2:6]1)(=[NH:3])[CH3:2].[ClH:32]>O>[ClH:32].[C:1]([NH:4][CH:5]1[CH2:6][N:7]([C:9]([C@@H:11]2[CH2:15][C@H:14]([S:16][C:17]3[C@H:18]([CH3:31])[C@@H:19]4[C@@H:26]([C@H:27]([OH:29])[CH3:28])[C:25](=[O:30])[N:20]4[C:21]=3[C:22]([OH:24])=[O:23])[CH2:13][NH:12]2)=[O:10])[CH2:8]1)(=[NH:3])[CH3:2]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 178465581HCID 178465581, compound

Product 1

HCID 178465582HCID 178465582, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

0.40 g of (1R,5S,6S)-2-[(2S,4S)-2-(3-Acetimidoylaminoazetidin-1-ylcarbonyl)pyrrolidin-4-ylthio]-6-[(1R)-1-hydroxyethyl]-1-methyl-1-carbapen-2-em-3-carboxylic acid (prepared as described in Example 122) was dissolved in 20 ml of cold water, 0.88 ml of 1N aqueous hydrochloric acid was added to the resulting solution, and the mixture was freeze-dried, to obtain 400 mg of the title compound as a colorless powder.

Workup

  1. customthe mixture was freeze-dried

Sources & evidence

ORD record
ord-4b5beaf2db48435ca9da9c438a6b0339
Source dataset
uspto-grants-1999_02
Patent number
US05866564

Reaction notes

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