HCID 123545774, compound → HCID 53784338, compound

HRID 362160Notes

Reaction equation

HRID 362160 reaction equation
Cl[SiH:2]1[CH2:7][CH2:6][CH:5]([C:8]2[CH:15]=[CH:14][C:11]([C:12]#[N:13])=[CH:10][CH:9]=2)[CH2:4][CH2:3]1>O1CCCC1>[CH2:3]([SiH:2]1[CH2:7][CH2:6][CH:5]([C:8]2[CH:15]=[CH:14][C:11]([C:12]#[N:13])=[CH:10][CH:9]=2)[CH2:4][CH2:3]1)[CH2:4][CH2:5][CH2:8][CH2:9][CH2:10][CH3:11]

Participants

3

Reactant 1

HCID 123545774HCID 123545774, compound

Product 1

HCID 53784338HCID 53784338, compoundYield 92%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

3.6 g (20 mmol) of 1-bromo-n-heptane was dropped into a mixture of 0.5 g of magnesium (21 mmol) and 50 ml of tetrahydrofuran (THF) to obtain Grignard reagent. This solution was then added to a mixture of 2.8 g of zinc chloride and 20 ml of THF to obtain the organozinc reagent. This solution was then dropped into a 50 ml THF solution of 4.7 g (20 mmol) of 4-(4-chloro -4-silacyclohexyl) benzonitrile to obtain 4-(4-n-heptyl -4-silacyclohexyl) benzonitrile.

Sources & evidence

ORD record
ord-8fcdb79823f14f3d929af54b60793f06
Source dataset
uspto-grants-1999_02
Patent number
US05868961

Reaction notes

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