Cyclopropylamine → HCID 470618, compound

HRID 362222Notes

Reaction equation

HRID 362222 reaction equation
F[C:2]1[C:7](/[CH:8]=[CH:9]\[C:10]2[C:11](F)=[N:12][CH:13]=[CH:14][CH:15]=2)=[CH:6][CH:5]=[CH:4][N:3]=1.[CH:17]1([NH2:20])[CH2:19][CH2:18]1>>[CH:17]1([N:20]2[C:2]3[N:3]=[CH:4][CH:5]=[CH:6][C:7]=3[CH:8]=[CH:9][C:10]3[CH:15]=[CH:14][CH:13]=[N:12][C:11]2=3)[CH2:19][CH2:18]1

Participants

3

Reactant 2

HCID 69828CyclopropylamineHCID 22942261Pyridine, 3,3′-(1Z)-1,2-ethenediylbis[2-fluoro-, (Z)-

Product 1

HCID 470618HCID 470618, compoundYield 54.9%

Conditions

Temperature
125 °C

Procedure

A mixture of Z-1,2-di-(2-fluoropyridinyl)ethylene (0.436 g) and cyclopropylamine (2 g) was heated at 125° C. in a sealed tube for 12 hours. The mixture was cooled and fractionated directly over silica gel to give 11-cyclopropyl-dipyrido[2,3-b:3',2'-f]azepine (0.258 g), mp 184°-185° C.

Workup

  1. temperatureThe mixture was cooled

Sources & evidence

ORD record
ord-610ebf02fa134b85954beeb6a44c9775
Source dataset
uspto-grants-1999_02
Patent number
US05869482

Reaction notes

Loading…