Potassium Carbonate → HCID 10846673, compound

HRID 362293Notes

Reaction equation

HRID 362293 reaction equation
O[C:2]1([CH3:18])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4](=[O:11])[N:3]1[C:12]1[CH:17]=[CH:16][N:15]=[CH:14][CH:13]=1.O=P12OP3(OP(OP(O3)(O1)=O)(=O)O2)=O.C([O-])([O-])=O.[K+].[K+]>>[CH2:18]=[C:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4](=[O:11])[N:3]1[C:12]1[CH:17]=[CH:16][N:15]=[CH:14][CH:13]=1

Participants

4

Reactant 3

HCID 11430Potassium CarbonateHCID 14812Phosphorus oxide (P4O10)HCID 10705200HCID 10705200, compound

Product 1

HCID 10846673HCID 10846673, compoundYield 66%

Conditions

Temperature
200 °C

Procedure

A mixture of 2,3-dihydro-3-hydroxy-3-methyl-2-(4-pyridyl)-1H-isoindol-1-one (10.20 g) and phosphorus pentoxide (6.03 g) was heated under vacuum at 200° C. for 20 minutes. Ice water was then added and the mixture was basified with K2CO3 solution. The resulting solid was filtered, dried and passed through a column of florisil (ethyl acetate) to give 6.23 g of a solid. A 2.0 g portion was recrystallized from methanol to give 1.37 gof platelets, mp: 173°-174° C.

Workup

  1. filtrationThe resulting solid was filtered
  2. customdried

Sources & evidence

ORD record
ord-3b568d21c92f4dec9fee81a0e02b0458
Source dataset
uspto-grants-1999_02
Patent number
US05869502

Reaction notes

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