Sodium Hydroxide → HCID 178441942, compound

HRID 36230Notes

Reaction equation

HRID 36230 reaction equation
[CH2:1]([C:5]1[N:6]([CH2:19][C:20]2[CH:25]=[CH:24][C:23]([C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][C:27]=3[C:32]3[NH:36][N:35]=[N:34][N:33]=3)=[CH:22][CH:21]=2)[C:7](=[O:18])[N:8]([CH:10]([C:14]([O:16]C)=[O:15])[CH:11]([CH3:13])[CH3:12])[N:9]=1)[CH2:2][CH2:3][CH3:4].[OH-].[Na+]>C1COCC1.CO.C(Cl)Cl>[CH2:1]([C:5]1[N:6]([CH2:19][C:20]2[CH:25]=[CH:24][C:23]([C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][C:27]=3[C:32]3[NH:36][N:35]=[N:34][N:33]=3)=[CH:22][CH:21]=2)[C:7](=[O:18])[N:8]([CH:10]([C:14]([OH:16])=[O:15])[CH:11]([CH3:12])[CH3:13])[N:9]=1)[CH2:2][CH2:3][CH3:4]

Participants

5

Reactant 2

HCID 14798Sodium HydroxideHCID 1784419415-n-Butyl-2-[1-(carbomethoxy)isobutyl]-2,4-dihydro-4-[[2'-(5-tetrazolyl)biphenyl-4-yl]methyl]-3H-1,2,4-triazol-3-one

Product 1

HCID 178441942HCID 178441942, compound

Reagents, catalysts & solvents 2

HCID 8028TetrahydrofuranSolventHCID 21226129Dichloromethane methanolSolvent

Procedure

The hydrolysis of 5-n-butyl-2-[1-(carbomethoxy)isobutyl]-2,4-dihydro-4-[[2'-(5-tetrazolyl)biphenyl-4-yl]methyl]-3H-1,2,4-triazol-3-one (from Example 38) using methanolic sodium hydroxide in THF was carried out as described in Example 7. The material obtained after work-up (71%) was homogeneous by TLC in 10% MeOH/CH2Cl2, mass spectrum (FAB) m/e 475 (M+1)+.

Workup

  1. customThe material obtained after work-up (71%)

Sources & evidence

ORD record
ord-028e008018d94746b369ce351d0fcf6d
Source dataset
uspto-grants-1995_05
Patent number
US05411980

Reaction notes

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